The region's topography is dominated by the Andes Mountains, including peaks like Illimani and Huayna Potosí. It also features the Altiplano plateau and is near Lake Titicaca, the highest navigable lake in the world (Altiplano, Lake Titicaca).

The climate is characterized by cool temperatures due to the high altitude, with average temperatures ranging from 35°F (2°C) to 55°F (13°C). Rain is common during the wet season from November to March, and snow is possible in the highest areas.

The two most common languages spoken are Spanish and Aymara.

The three largest religious denominations in the area are Roman Catholicism, Evangelicalism, and Pentecostalism.

Mining: Mining is a major industry, with significant production of tin, silver, and other minerals. Companies like COMIBOL excel in this market.

Manufacturing: The manufacturing sector includes food processing, textiles, and garments. Cervecería Boliviana Nacional is a notable employer.

Retail and Commerce: Retail and commerce are vital, with numerous local and international businesses operating in the area. The La Paz Shopping Mall is a significant commercial hub.

Major local celebrations include the Fiesta del Gran Poder, a vibrant religious festival featuring colorful parades and traditional dances; the Aymara New Year, celebrating indigenous culture and heritage; and the Carnaval de Oruro, known for its elaborate costumes and folk dances.

Key tourist attractions include the Valley of the Moon, an otherworldly landscape of eroded rock formations; the Witches' Market, offering unique local crafts and traditional medicines; and the La Paz Cathedral, a historic and architectural landmark.

Popular recreational activities include hiking and trekking in Condoriri Massif, known for its scenic trails and mountaineering opportunities, and exploring the Sajama National Park, which features hot springs, geysers, and wildlife. Major parks in the area include the Tunari National Park and the Madidi National Park.