The region's topography includes the Andes Mountains to the west and the vast Amazon Basin to the north and east. Notable natural features include the Amboró National Park and the Madeira River.

Santa Cruz experiences a tropical savanna climate with distinct wet and dry seasons. Average temperatures range from 70°F (21°C) to 90°F (32°C) throughout the year, with high humidity and frequent rainfall during the summer months.

The two most common languages spoken are Spanish and Guarani.

The three largest religious denominations in the area are Roman Catholicism, Evangelicalism, and Pentecostalism.

Agriculture: Agriculture is a key industry, with major crops including soybeans, sugarcane, and cotton. Companies like AGSA Group excel in this market.

Manufacturing: The manufacturing sector includes food processing, textiles, and construction materials. Saguapac is a notable employer in this sector.

Energy: The energy sector is significant, with production of natural gas and petroleum. YPFB Corporation is a major player in this industry.

Major local celebrations include the Carnaval de Santa Cruz, featuring colorful parades and traditional dances; the Fiesta de La Cruz, which celebrates the Holy Cross with processions and music; and the ExpoCruz, an international trade fair showcasing local and international products.

Key tourist attractions include the Jardin Botanico, a botanical garden showcasing local flora; the Biocentro Güembé, a natural reserve with wildlife and recreational activities; and the Noel Kempff Mercado National Park, known for its biodiversity and stunning landscapes.

Popular recreational activities include hiking and birdwatching in the Lomas de Arena sand dunes, and exploring the Kaa-Iya del Gran Chaco National Park, which is home to jaguars and other wildlife.